This episode offers a scientific overview of psilocybin—what it is chemically, how it works at the cellular and neural circuit levels, and how it promotes neuroplasticity, the brain’s ability to rewire itself in ways that shape emotional, cognitive, and behavioral patterns. It covers findings from clinical trials exploring psilocybin’s potential in treating depression, addiction, and other psychiatric conditions. The discussion includes typical phases of a psilocybin experience, common dosage categories, and the critical role of set, setting, and support. It also outlines which populations may be at risk and which may benefit, while examining the evolving legal and medical landscape. A useful listen for anyone interested in the intersection of psychedelics, mental health, and brain science.